Viral Proteins Counteracting Host Defenses
Produktnummer:
18cffe30d4186c420c8e49f1e51771e452
| Themengebiete: | Antigen processing Chemokine antigen antigen presentation antiviral response apoptosis cytomegalovirus gene histocompatibility immune system |
|---|---|
| Veröffentlichungsdatum: | 14.10.2011 |
| EAN: | 9783642639746 |
| Sprache: | Englisch |
| Seitenzahl: | 325 |
| Produktart: | Kartoniert / Broschiert |
| Herausgeber: | Hengel, H. Koszinowski, U.H. |
| Verlag: | Springer Berlin |
Produktinformationen "Viral Proteins Counteracting Host Defenses"
Since the first observations of viral interference with antigen presentation in the MHC class-I pathway, the field has advanced to a detailed analysis. We know numerous genes and for some of them we have profound information on their mechanistic function. The antigen presentation pathway is affected at all stages starting from proteasomal degradation of an antigenic viral protein, as shown for EBV, transfer of the proteasomal cleavage products as peptides in the ER by specific transporters, the loading of the nascent MHC class-I molecule, and finally the transport of the complex to the surface and presentation in a normal or deranged form. All these different steps of the MHC class-I antigen presentation pathway are targets for viral proteins. Not only MHC class-I but also MHC class-II proteins are a target of viral influence either by direct downregulation and degradation of proteins or by interference of signal transduction pathways.
Sie möchten lieber vor Ort einkaufen?
Sie haben Fragen zu diesem oder anderen Produkten oder möchten einfach gerne analog im Laden stöbern? Wir sind gerne für Sie da und beraten Sie auch telefonisch.
Juristische Fachbuchhandlung
Georg Blendl
Parcellistraße 5 (Maxburg)
8033 München
Montag - Freitag: 8:15 -18 Uhr
Samstags geschlossen