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The Neuroimmunological Basis of Behavior and Mental Disorders

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Produktnummer: 1800dae30e23324c09b7970fdc2b8e1eb8
Themengebiete: Interferon cytokines depression emotional disorders genetics neorimmunology psychiatry psychopharmacology schizophrenia sickness behavior
Veröffentlichungsdatum: 14.11.2008
EAN: 9780387848501
Sprache: Englisch
Seitenzahl: 438
Produktart: Gebunden
Herausgeber: Siegel, Allan Zalcman, Steven S.
Verlag: Springer US
Produktinformationen "The Neuroimmunological Basis of Behavior and Mental Disorders"
For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter “Cytokines and the Blood–Brain Barrier” p- vides insight into interactions between the blood–brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter “Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines,” the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.
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