Structure-based Drug Discovery
Produktnummer:
186019a2dc46aa455693b7925aad9a1da5
| Themengebiete: | Computational chemistry Drug discovery Fragment - based NMR Protein structure Structural genomics X-ray crystallography biology chemistry |
|---|---|
| Veröffentlichungsdatum: | 19.10.2010 |
| EAN: | 9789048171231 |
| Sprache: | Englisch |
| Seitenzahl: | 250 |
| Produktart: | Kartoniert / Broschiert |
| Herausgeber: | Jhoti, Harren Leach, Andrew R. |
| Verlag: | Springer Netherland |
Produktinformationen "Structure-based Drug Discovery"
Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.
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