Signaling Through the Cell Matrix

Topological Constraints Carry Signaling from the Cell Matrix to the Genome.- 1 Variation in Cell Adhesion During Proliferation of Normal Cells.- 2 Coupling Between Changes in Cell Adhesion and Proliferation of Transformed Cells.- 3 Mechanisms of Cell Adhesion-Mediated Changes in the Cell Phenotype.- 4 Conclusions.- References.- The Transmission of Contractility Through Cell Adhesion.- 1 Introduction.- 2 Generation of Contractility.- 3 Molecular Mechanism of Force Transmission.- 4 Regulation of Contractility Transmission.- 5 Interaction Between Contraction Force and ECM.- 6 Myofibroblasts and Wound Healing.- 7 Muscle.- 8 Conclusion.- References.- Role of Focal Adhesion Kinase in Signaling by the Extracellular Matrix.- 1 Introduction.- 2 FAK Activation by Integrin.- 3 FAK Downstream Pathways.- 4 Biological Functions of FAK in Signaling by ECM.- References.- Interaction Between Cells and Extracellular Matrix: Signaling by Integrins and the Elastin-Laminin Receptor.- 1 Introduction.- 2 Cell-Matrix Interactions Mediated by Integrins.- 3 Cell-Matrix Interactions Mediated by the Elastin-Laminin Receptor.- 4 Discussion and Conclusions.- References.- Regulation of Gene Expression by Changes in Cell Adhesion.- 1 Introduction.- 2 Regulation of Cell Proliferation by Cell Adhesion.- 3 Regulation of Cell Differentiation by Cell Adhesion.- 4 Conclusion.- References.- Expression of Liver Specific-Genes in Hepatocytes Cultured in Collagen Gel Matr.- 1 Introduction.- 2 Culture of Hepatocytes in Collagen Gel.- 3 Hepatic Specific Functions of Hepatocytes in Collagen Cultures.- 4 Biotransformation Capability: Basal and Induced Levels of Drug-Metabolizing Enzymes.- 5 Expression of Hepatic Transcription Factors.- 6 Concluding Remarks.- References.- Collagen Type I: A Substrate and a Signal for Invasion.- 1 Introduction.- 2 Invasion into Matrices.- 3 Effects of Collagen on the Invasive Behavior of Cells.- 4 A Scenario for the Molecular Cross Talk Between Collagen and Cell.- 5 Conclusion.- References.