Non-Myeloablative Allogeneic Transplantation
Produktnummer:
189727d385b2b64de883706be7f6c06f31
| Themengebiete: | Immunosuppression bone marrow cell hematopoietic stem cell hematopoietic stem cell transplantation immunotherapy lymphocytes morbidity mortality stem cell |
|---|---|
| Veröffentlichungsdatum: | 28.02.2002 |
| EAN: | 9780792376460 |
| Sprache: | Englisch |
| Seitenzahl: | 216 |
| Produktart: | Gebunden |
| Herausgeber: | Ball, Edward D. Bashey, Asad |
| Verlag: | Springer US |
Produktinformationen "Non-Myeloablative Allogeneic Transplantation"
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.
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