mTOR Inhibition for Cancer Therapy: Past, Present and Future
| Themengebiete: | Arznei / Arzneimittellehre Biologie / Molekularbiologie Forschung (medizinisch, psychologisch) Heilkunde Humanmedizin Hämatologie Krebs (Krankheit) Krebs (Krankheit) / Onkologie Medizin Molekularbiologie Onkologie - Radioonkologie Pharmakologie Tumor / Krebs |
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| Veröffentlichungsdatum: | 01.12.2015 |
| EAN: | 9782817804910 |
| Auflage: | 001 |
| Sprache: | Englisch |
| Seitenzahl: | 308 |
| Produktart: | Gebunden |
| Herausgeber: | Mita, Alain Mita, Monica Rowinsky, Eric K. |
| Verlag: | Springer France S.A.R.L. Springer Paris |
Produktinformationen "mTOR Inhibition for Cancer Therapy: Past, Present and Future"
This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compoundscurrently under evaluation.
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