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Immunodiagnosis and Immunotherapy of Malignant Tumors

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Produktnummer: 180deba6a27ec94e2a8ca6661b57e3c40e
Themengebiete: antigen breast cancer cancer cancer therapy diagnosis diseases growth immunology immunotherapy neoplasm
Veröffentlichungsdatum: 15.03.1979
EAN: 9783540091615
Sprache: Englisch
Seitenzahl: 331
Produktart: Kartoniert / Broschiert
Herausgeber: Betzler, M. Flad, H.-D. Herfarth, C.
Verlag: Springer Berlin
Untertitel: Relevance to Surgery
Produktinformationen "Immunodiagnosis and Immunotherapy of Malignant Tumors"
The concept of immunologic responses against tumors is currently under intense scrutiny throughout the world. The evidence for the existence of tumor-specific transplantation antigens (TSTA) and specific immune reactions to them in experimental animals is overwhelming. The available data concerning human tumors are controversial. The reason for this is partially that antigens detectable on human tumors by in vitro assays have not been biologically characterized. In other words, we do not know if the antigens on human tumors are acting as the targets for immunologically mediated rejection processes in vivo. It was the purpose of this workshop to bring experimental tumor immunologists and clinical oncologists together in order to disclose facts and limits in tumor immunology. Clinicians were to learn how shaky the ground becomes once the experimentalist looks beyond the edge of the mouse cage. Tumor biologists heard the clinicians' urgent cry for controlled randomized trials of immunotherapy which thus reflects clearly that immunotherapy in its present form without knowledge of dose-effect-relationship does not work. Nobody would deny that the problem of human cancer smells of immunology, but since we are just about to taste it the essential ingredient might be different. In other words one might look at present rather at immunological epiphenomena than at mechanisms of tumor immul1lty operating in vivo. This problem was among others a central issue of this workshop.
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