Etiology and Morphogenesis of Congenital Heart Disease

Part I. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now and Future .- Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine.- The arterial epicardium, a developmental approach to cardiac disease and repair.- Cell sheet tissue engineering for heart failure.- Future treatment of heart failure and pathophysiological analysis of various heart diseases using human iPS cell-derived cardiomyocytes.- Congenital heart disease: in search of remedial etiologies.- Part II. Left-Right Axis and Heterotaxy Syndrome.- Left-right Asymmetry and Human Heterotaxy Syndrome.- Roles of motile and immotile cilia in left-right symmetry breaking.- Role of cilia and left-right patterning in congenital heart disease.- Pulmonary arterial hypertension in patients with heterotaxy /polysplenia syndrome.- Part III. Cardiomyocyte and Myocardial Development.- Single Cell Expression Analyses of Embryonic Cardiac Progenitor Cells.- Meis1 Regulates Post-Natal Cardiomyocyte Cell Cycle Arrest.- Intercellular signalling in cardiac development and disease: NOTCH.- The epicardium in ventricular septation during evolution and development.- S1P-S1p2 signaling in cardiac precursor cells migration.- Myogenic progenitor cell differentiation is dependent on modulation of mitochondrial biogenesis through autophagy.- The role of the thyroid in the developing heart.- Part IV. Valve Development and Diseases.- Atrioventricular valve abnormalities: From molecular mechanisms underlying morphogenesis to clinical perspective.- Molecular Mechanisms of Heart Valve Development and Disease.- A novel role for endocardium in perinatal valve development: Lessons learned from tissue specific gene deletion of the Tie1 receptor tyrosine kinase.- The Role of the Epicardium in the Formation of the Cardiac Valves in the Mouse.- TMEM100, a novel intracellular transmembrane protein essential for vascular development and cardiac morphogenesis.- Cell autonomous regulation of BMP-2 in endocardial cushion cells during AV valvuloseptal morphogenesis.- Part V. The Second Heart Field and Outflow Tract.- Properties of cardiac progenitor cells in the second heart field.- Nodal signaling and congenital heart defects.- Utilizing Zebrafish to Understand Second Heart Field Development.- A history and interaction of outflow progenitor cells implicated in "Takao syndrome".- The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse.- Environmental modification for phenotype of truncus arteriosus in Tbx1 hypomorphic mice.- Part VI. Vascular Development and Diseases.- Extracellular matrix remodeling in vascular development and disease.- The "cardiac neural crest" concept revisited.- Roles of endothelial Hrt genes for vascular development.- Placental Expression of Type 1 and 3 Inositol Trisphosphate Receptors is Required for the Extra-embryonic Vascular Development.- Tissue Remodeling in Vascular Wall in Kawasaki Disease-related Vasculitis Model Mice.- Part VII. Ductus Arteriosus.- Progerin expression during normal closure of the human ductus arteriosus: A case of premature ageing?.- The multiple roles of prostaglandin E2 in the regulation of the ductus arteriosus.- Developmental Differences in the Maturation of Sarcoplasmic Reticulum and Contractile Proteins in Large Blood Vessels Influences Their Contractility.- Fetal and Neonatal Ductus Arteriosus is Regulated with ATP-sensitive Potassium Channel.- Part VIII. Conduction System and Arrhythmia.- Regulation of vertebrate conduction system development.- Cardiac Pacemaker Development from a Tertiary Heart Field.- Endothelin receptor type A expressing cell population in the inflow tract contributes to chamber formation.- Specific isolation of HCN4 positive cardiac pace-making cells derived from embryonic stem cell.- Part IX. Current Molecular Mechanism in Cardiovascular Development.- Combinatorial functions of transcription fa