Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of a-Aryl Ketones
Doran, Robert
Produktnummer:
18c383d26a34444200be405bbb963281b8
Autor: | Doran, Robert |
---|---|
Themengebiete: | Antimicrobial Activity Asymmetric Synthesis Catalytic Asymmetric Synthesis Dual Stereocontrol Natural Product Analogues Total Synthesis |
Veröffentlichungsdatum: | 15.10.2016 |
EAN: | 9783319370347 |
Sprache: | Englisch |
Seitenzahl: | 202 |
Produktart: | Kartoniert / Broschiert |
Verlag: | Springer International Publishing |
Produktinformationen "Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of a-Aryl Ketones"
This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

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